THE MEDICINE OF TOMORROW

How could we fight bacterial infections without antibiotics?

Since the discovery of penicillin in 1928, the use of antibiotics to treat several bacterial infections has grown exponentially. However, this has led to a growth in antibiotic resistance by the pathogenic bacteria, leaving us with no effective ways to fight those diseases.

The challenge will be to develop new treatment ideas or approaches to fight bacterial infections effectively.

The Challenge

Since the discovery of penicillin in 1928, the use of antibiotics to treat several bacterial infections has grown exponentially. However, this has led to a growth in antibiotic resistance by the pathogenic bacteria, leaving us with no effective ways to fight those diseases. Your challenge is to develop new treatment ideas or approaches to fight bacterial infections effectively.

Background

Since the discovery of penicillin in 1928, the use of antibiotics to treat several bacterial infections has grown exponentially. Antibiotics have been widely used to treat bacterial infections such as pneumonia, strep throat, and urinary tract infections. However, the overuse and misuse of antibiotics have led to a growth in antibiotic resistance by the pathogenic bacteria. This phenomenon, known as antibiotic resistance, is the ability of bacteria to resist the effects of antibiotics. This means that the drugs that were once effective in treating these infections are no longer working. The World Health Organization (WHO) has declared antibiotic resistance as one of the most critical global health threats of our time.

Objective

The objective of this challenge is to develop new treatment ideas or approaches to fight bacterial infections effectively. This can be achieved by identifying new targets for drug development, investigating the use of combination therapies, understanding the mechanisms of antibiotic resistance, and finding alternatives to traditional antibiotics.

Potential Considerations

As you develop your solution, you may (but are not required to) consider the following:

  • Finding alternatives to traditional antibiotics: With the increasing prevalence of antibiotic resistance, there is a need to find alternatives to traditional antibiotics. This can include the use of natural compounds, such as essential oils and herbs, that have antimicrobial properties. Additionally, research into phage therapy, which uses viruses to target and kill specific bacteria, is a promising alternative to traditional antibiotics.
  • Identifying new targets for drug development: Antibiotic resistance occurs when bacteria evolve to resist the drugs that are meant to kill them. One way to overcome this is to develop new drugs that target different parts of the bacterial cell. This can include identifying new antibiotic targets, such as bacterial enzymes or metabolic pathways, and developing drugs that target these new targets.
  • Investigating the use of combination therapies: Combination therapy involves using multiple drugs to treat a single infection. This can help to reduce the development of antibiotic resistance by preventing bacteria from developing resistance to a single drug. Combination therapy also increases the chances of bacteria being killed by multiple drugs.
  • Understanding the mechanisms of antibiotic resistance: Understanding how bacteria develop resistance to antibiotics is crucial for developing new treatments. This includes studying the genetic changes that occur in bacteria when they become resistant to antibiotics, as well as identifying the environmental factors that contribute to the development of antibiotic resistance.

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